Quick Reference

Reporting Criteria

Standardised scoring systems and response criteria used in PET reporting. Reference guides and visual graphics coming soon โ€” organised by tracer and clinical application.

Deauville PERCIST miPSMA / PROMISE Krenning Score RANO-NM Lugano Classification
Lymphoma Solid Tumors NETs & DOTATATE PSMA Brain PET Thyroid
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Visual Reference Graphics Coming Soon

Printable one-page graphics for each scoring system โ€” Deauville 5-point scale, Krenning score, miPSMA, RANO-NM, and more. Designed to be kept at your workstation. Key guidelines and references are available now below.

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Lymphoma

FDG PET response assessment in lymphoma is governed by the Lugano Classification and Deauville 5-point scale. Liver is always the reference organ.

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Deauville 5-Point Scale
Score 1โ€“5 based on uptake relative to mediastinum (scores 1โ€“2) and liver (scores 3โ€“5). Score 4โ€“5 = residual disease. Used for interim and end-of-treatment assessment.
Mediastinum referenceLiver referenceInterim PETEnd of treatment
Visual Guide Coming Soon
Lugano Classification
Replaces Cheson 2007. Integrates PET and CT response criteria. Defines complete metabolic response (CMR), partial metabolic response (PMR), and progressive metabolic disease (PMD).
CMRPMRPMDCT + PET integrated
Key Guideline
Lugano Classification โ€” Cheson et al, Journal of Clinical Oncology, 2014
The standard reference for lymphoma response criteria integrating PET and CT.
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Solid Tumors

PERCIST defines metabolic response in solid tumors using SULpeak measurements. RECIST 1.1 remains the anatomic complement โ€” both are often reported together.

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PERCIST 1.0
PET Response Criteria in Solid Tumors. Uses SULpeak (lean body mass corrected SUV) of the most active lesion. Defines complete, partial, stable, and progressive metabolic disease.
SULpeakCMRPMR โ‰ฅ30% decreasePMD โ‰ฅ30% increase
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EORTC Criteria
Earlier metabolic response criteria using SUVmax. Still referenced in some trials. PERCIST is now preferred for most solid tumor applications.
SUVmax basedTrial useHistorical reference
Key Guideline
PERCIST โ€” Wahl et al, Journal of Nuclear Medicine, 2009
The foundational paper defining metabolic response criteria for solid tumors.
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NETs & DOTATATE

Krenning score quantifies DOTATATE uptake relative to liver at each disease site. All lesions must meet the threshold for PRRT eligibility โ€” one low-avidity site excludes a patient.

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Krenning Score
1 = very low (less than liver), 2 = low (equal to liver), 3 = moderate (greater than liver), 4 = high (greater than spleen). Score โ‰ฅ3 at all sites required for PRRT eligibility. Always use liver as reference โ€” never spleen.
Score 1โ€“4Liver referencePRRT eligibilityPer lesion scoring
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RECIST for NETs
Anatomic response criteria used alongside DOTATATE for treatment monitoring. SUV changes on DOTATATE after PRRT correlate with clinical outcome.
Post-PRRT monitoringCT complementSUV reduction
Key Guideline
SNMMI Procedure Standard โ€” DOTATATE PET/CT, 2020
Patient selection criteria and reporting standards for somatostatin receptor PET.
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PSMA

miPSMA (PROMISE) scoring quantifies PSMA expression at each lesion site. Required for Lu-177 PSMA eligibility assessment โ€” all lesions must score โ‰ฅ3.

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miPSMA Score (PROMISE)
Molecular Imaging TNM (miTNM) system. miPSMA scores 1โ€“5: 1 = very low, 2 = low, 3 = intermediate, 4 = high, 5 = very high. Score โ‰ฅ3 at all lesion sites required for PLUVICTO eligibility per VISION trial criteria.
Score 1โ€“5PLUVICTO eligibilityVISION criteriaPer lesion
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miTNM Staging
Molecular imaging TNM system for prostate cancer. Classifies primary (miT), nodal (miN), and metastatic (miM) disease based on PSMA PET findings. Complements pathologic staging.
miT stagingmiN stagingmiM stagingBCR localisation
Key Guideline
PROMISE โ€” Eiber et al, European Urology, 2018
The standardised framework for PSMA PET reporting and miPSMA scoring.
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Brain PET

Brain PET reporting criteria span multiple tracers and clinical applications โ€” from amyloid visual reads to glioma response assessment.

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Amyloid PET Visual Read
Binary positive/negative visual read. Positive = loss of grey-white matter contrast with cortical tracer retention. Posterior cingulate and precuneus are the earliest and most sensitive regions.
Positive / NegativeGrey-white contrastPosterior cingulateCentiloid scale
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RANO-NM โ€” Brain Tumor Response
Response Assessment in Neuro-Oncology for Nuclear Medicine. Uses TBR (tumour-to-background ratio) thresholds on amino acid PET. Defines complete, partial, and progressive metabolic disease for glioma.
TBRmax thresholdFET / FDOPAGlioma responsePseudoprogression
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Braak Staging โ€” Tau PET
Six-stage framework describing the anatomical spread of tau pathology from medial temporal lobe (Braak Iโ€“II) through neocortex (Braak Vโ€“VI). Correlates with clinical severity.
Braak Iโ€“VIMTL spreadFlortaucipirClinical correlation
Key Guideline
RANO-NM Criteria โ€” Galldiks et al, Lancet Oncology, 2021
Standardised response criteria for amino acid PET in neuro-oncology.
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Thyroid

Radioiodine therapy for differentiated thyroid cancer involves diagnostic ยนยฒยณI scanning followed by ยนยณยนI ablation. Response is assessed by thyroglobulin levels and post-therapy scan.

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Post-Therapy ยนยณยนI Scan Reporting
Whole body scan 5โ€“8 days post RAI ablation. Documents remnant thyroid tissue, locoregional disease, and distant metastases. Correlated with stimulated thyroglobulin.
ยนยณยนI RAIRemnant ablationThyroglobulinPost-therapy scan
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ATA Risk Stratification
American Thyroid Association risk stratification guides RAI use and follow-up intensity. Low, intermediate, and high risk categories determine whether ablation is indicated.
Low riskIntermediate riskHigh riskRAI indication
Key Guideline
ATA Guidelines โ€” Thyroid Cancer Management, 2015
American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer.
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All Key References